GI ToolsGastroenterology and hepatology

Lille model

The Lille model uses the change in bilirubin over the first week of prednisolone to identify non-responders, in whom steroids can be stopped. It is validated at day 7, and performs similarly at day 4.

Results
Renal insufficiency (creatinine above 115 µmol/L, 1.3 mg/dL)

Enter the values above.

How it is worked out

R = 3.19 − 0.101 × age + 0.147 × albumin (g/L) + 0.0165 × (bilirubin day 0 − bilirubin day 7, µmol/L) − 0.206 × renal insufficiency − 0.0065 × bilirubin day 0 (µmol/L) − 0.0096 × prothrombin time (seconds). Lille score = e−R ÷ (1 + e−R).

Reference

Louvet A, Naveau S, Abdelnour M, et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology. 2007;45(6):1348-1354.