GI ToolsGastroenterology and hepatology

NAFLD fibrosis score

The NAFLD fibrosis score (NFS) estimates the likelihood of advanced fibrosis (F3 to F4) in MASLD. The MASLD fibrosis panel works out FIB-4, NFS, APRI and BARD together from one set of results.

Patient
Type 2 diabetes or impaired fasting glucose
Blood results

Enter the values above.

Related resources: MASLD

How it is worked out

NFS = −1.675 + 0.037 × age + 0.094 × BMI + 1.13 × diabetes or IFG + 0.99 × AST/ALT − 0.013 × platelets − 0.66 × albumin (g/dL). Below −1.455 (0.12 from age 65) makes advanced fibrosis unlikely; above 0.676 makes it likely.

References

Angulo P, Hui JM, Marchesini G, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 2007;45(4):846-854.

McPherson S, Hardy T, Dufour JF, et al. Age as a confounding factor for the accurate non-invasive diagnosis of advanced NAFLD fibrosis. Am J Gastroenterol. 2017;112(5):740-751.