GI ToolsGastroenterology and hepatology

SAFE score

The Steatosis-Associated Fibrosis Estimator (SAFE) was developed to detect significant fibrosis (F2 or more) in steatotic liver disease in primary care, where FIB-4 was designed for advanced fibrosis.

Patient
Type 2 diabetes
Blood results

Total protein minus albumin.

Enter the values above.

Related resources: MASLD

How it is worked out

SAFE = 2.97 × age + 5.99 × BMI (capped at 40) + 62.85 × diabetes + 154.85 × ln AST − 58.23 × ln ALT + 195.48 × ln globulin (g/dL) − 141.61 × ln platelets − 75.

Reference

Sripongpun P, Kim WR, Mannalithara A, et al. The steatosis-associated fibrosis estimator (SAFE) score: a tool to detect low-risk NAFLD in primary care. Hepatology. 2023;77(1):256-267.